Common Variable Immune Deficiency (CVID)
CVID is a disorder characterized by impaired B-cell differentiation, leading to reduced antibody production and increased susceptibility to infections.

Signs and Symptoms:

1. Recurring infections (sinus, lung, gastrointestinal, skin)
2. Bronchiectasis (chronic lung disease)
3. Chronic diarrhea or gastrointestinal issues
4. Fatigue
5. Weight loss
6. Swollen lymph nodes
7. Autoimmune disorders (e.g., rheumatoid arthritis)
8. Granulomatous disease (inflammation in organs)

Treatment Options:

1. Immunoglobulin replacement therapy (IGRT):
   1. Intravenous (IVIG) or subcutaneous (SCIG) administration
   2. Replaces deficient antibodies
2. Antibiotic prophylaxis:
   1. Prevents infections
   2. Often used in conjunction with IGRT
3. Management of complications:
   1. Bronchiectasis: Chest physiotherapy, antibiotics
   2. Autoimmune disorders: Immunosuppressive medications
   3. Granulomatous disease: Corticosteroids, immunosuppressants
4. Lifestyle modifications:
   1. Good hygiene practices
   2. Avoid close contact with individuals with infections
   3. Regular follow-up with healthcare provider

Additional Considerations:

1. Genetic counseling (if familial CVID suspected)
2. Monitoring for lymphoma or other cancers
3. Avoid live vaccines due to increased risk of infection

Consult an immunologist or healthcare professional for personalized diagnosis and treatment, as CVID requires individualized care.