Calprotectin is a protein found in white blood cells that can be detected in stool. Elevated levels of fecal calprotectin indicate inflammation in the gastrointestinal (GI) tract.
Normal Range:
Typically, fecal calprotectin levels below 50 μg/g are considered normal.
Some laboratories may use slightly different cutoffs.
Interpretation:
Elevated levels (above 50 μg/g):
May suggest inflammatory bowel disease (IBD), such as Crohn’s disease or ulcerative colitis.
Can also indicate other GI infections or conditions, such as celiac disease.
Low levels (below 50 μg/g):
Generally indicate no significant inflammation in the GI tract.
However, low levels can also occur in individuals with IBD who are in remission.
Factors Affecting Levels:
Age: Calprotectin levels tend to be higher in younger children.
Medications: Certain medications, such as corticosteroids and NSAIDs, can elevate calprotectin levels.
Infections: Bacterial, viral, or parasitic infections can cause increased calprotectin production.
Clinical Use:
Fecal calprotectin testing can help diagnose IBD and monitor its activity.
It can also be used to assess the severity of GI inflammation and guide treatment decisions.
In individuals with suspected IBD, a high calprotectin level may warrant further investigation, such as colonoscopy or endoscopy.
Additional Notes:
Calprotectin levels can fluctuate over time.
A single elevated calprotectin level does not always indicate a serious condition.
It is important to consult with a healthcare professional for proper interpretation of fecal calprotectin test results.