Purpose: 

The cosyntropin stimulation test is a medical procedure used to assess the function of the adrenal glands. It measures the body’s response to a synthetic hormone called cosyntropin, which is similar to the natural hormone adrenocorticotropic hormone (ACTH). 

Procedure: 

• The test is usually performed in the morning.
• A small amount of cosyntropin is injected intravenously.
• Blood samples are taken before and after the injection to measure cortisol levels.Â

Interpretation: 

• Normal results indicate that the adrenal glands are functioning properly and respond adequately to ACTH stimulation.Â
• Low cortisol levels after the injection may suggest adrenal insufficiency, a condition in which the adrenal glands do not produce enough cortisol.Â
• High cortisol levels may indicate Cushing’s syndrome, a condition in which the body produces too much cortisol.Â

Indications: 

Suspected adrenal insufficiency, Addison’s disease, Congenital adrenal hyperplasia, and Pituitary gland disorders. 

Precautions: 

• People with certain medical conditions, such as Cushing’s syndrome or adrenal crisis, may not be able to undergo this test.Â
• Pregnant women should consult their doctor before undergoing this test.Â
• Side effects are generally mild and may include injection site pain, redness, or swelling.Â

Additional Information:

• The test is also known as the ACTH stimulation test.Â
• A low-dose cosyntropin test may be used to diagnose secondary adrenal insufficiency, which is caused by a problem with the pituitary gland.Â
• The results of the test may take several days to be available.Â