The key difference between CLL (chronic lymphocytic leukemia) and CML (chronic myeloid leukemia) is the type of blood cell affected: CLL originates in lymphocytes, while CML starts in myeloid cells, meaning CLL impacts the white blood cells specifically called lymphocytes, whereas CML affects the cells that produce different types of blood cells including red blood cells and platelets; this difference leads to distinct genetic abnormalities, symptoms, and treatment approaches for each condition. 

Key points to differentiate CLL and CML:

• Cell type affected:CLL affects lymphocytes, while CML affects myeloid cells.Â
• Genetic marker:CML is often characterized by the Philadelphia chromosome (BCR-ABL1 fusion gene), which is not typically present in CLL.Â
• Symptoms:CLL may present with swollen lymph nodes, fatigue, and recurrent infections, while CML can cause abdominal discomfort, splenomegaly, and bone pain.Â
• Diagnosis:CLL is diagnosed through blood tests showing a high lymphocyte count and flow cytometry, while CML is confirmed by bone marrow biopsy and identifying the Philadelphia chromosome.Â
• Treatment:CLL treatment options include chemotherapy, immunotherapy, and targeted therapies, while CML is primarily managed with tyrosine kinase inhibitors (TKIs) that target the BCR-ABL1 fusion protein.Â