Cardiac myxomas can cause weight loss primarily due to the release of cytokines, particularly interleukin-6 (IL-6), by the tumor cells. IL-6 is associated with systemic inflammation and can lead to symptoms like fatigue, fever, and weight loss. Additionally, the tumor’s growth can affect the heart’s ability to pump blood efficiently, potentially leading to reduced nutrient absorption and further weight loss. 

Elaboration:

• Cytokine Production:Myxoma cells release inflammatory cytokines, including IL-6, which can trigger a systemic inflammatory response.Â
• IL-6 and Weight Loss:IL-6 is known to be involved in metabolic changes, including increased protein breakdown and decreased appetite, both of which can contribute to weight loss.Â
• Heart Function Impact:The growth of a myxoma can obstruct blood flow within the heart chambers, affecting the heart’s ability to pump blood efficiently. This can lead to reduced nutrient delivery to tissues, potentially causing weight loss.Â
• Other Factors:While cytokine production is the primary mechanism, other factors like impaired nutrient absorption due to gastrointestinal issues or the presence of other systemic inflammatory conditions can also contribute to weight loss in individuals with myxomas.Â